Endocrine Abstracts

IGF1 concentrations have been reported to increase with 25-hydroxyvitamin D (25(OH)D) values in population studies, but it is unclear whether this association expresses a cause-effect relationship. Mice genetically deficient of steroid receptor coactivator 3, a transcriptional coactivator for the nuclear vitamin D receptor, have significantly lower circulating IGF1 levels than wild-types.We measured serum fasting 25(OH)D and IGF1 by enzyme- and radioimmu...

Gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) are rare neoplasms with heterogeneous clinical behavior and potential long-term survival. In the last decade GEP–NET nomenclature has been twice reviewed. However, the 2000 WHO classification had poor prognostic power in well differentiated (WD) neoplasms. This led to the introduction of two new important parameters by the European Neuroendocrine Tumors Society (ENETS), grade and stage; the former became part of t...